@article {274,
	title = {The effects of solvent extracts ofCitrulluslanatusseeds andChrysophyllumalbidumcotyledons on rat hepatocyte regeneration, cytochrome c oxidaseactivities and bacteriocin- producing gram-negative bacteria},
	journal = {PharmacologyOnLine},
	volume = {3},
	year = {2019},
	pages = {165-184},
	abstract = {Medicinal plants have been shown to exert a plethora of biological and pharmacological which has\&nbsp;been associated with the presence of several bioactive components. In this study, the effects of crude\&nbsp;extracts of Citrullus lanatus seeds (CACL) and Chrysophyllum albidum cotyledons (CACA) on rat\&nbsp;hepatocyte regeneration, liver cytochrome c oxidase activities, and their antimicrobial properties on a\&nbsp;few bacteriocin-producing Gram-negative bacteria were determined. CACL and CACA were screened\&nbsp;for the presence of amino acids using TLC sprayed with ninhydrin, pyridine and modified Commassie\&nbsp;brilliant blue (G250). The amino acids were elucidated by Gas Chromatography-Mass Spectrometry\&nbsp;(GC/MS) and Fourier-transform infrared spectroscopy (FTIR). CACA enhanced tissue regeneration in rat\&nbsp;hepatocytes, in situ and increased the collagen content. CACA also enhanced the activity cytochrome c\&nbsp;oxidase in the liver mitochondrial portion, but inhibited same in the homogenate. CACA and CACL did\&nbsp;not inhibit the bacteriocin-producing bacteria at the different concentrations tested. It is evident that\&nbsp;CACA and CACL contain amino acids that can improve liver antioxidant functions and its mitochondrial\&nbsp;electron transport. Both amino acid-rich fractions, combined with bacteriocin may accelerate aseptic\&nbsp;wound healing.
Keywords: Tissue regeneration, catalase, cytochrome c oxidase, seed amino acids, Citrullus lanatus seeds, Chrysophyllum albidum cotyledons, bacteriocin-producing bacteria.},
	url = {https://pharmacologyonline.silae.it/files/archives/2019/vol3/PhOL_2019_3_A015_Molehin.pdf},
	author = {O. R. Molehin and E. I. O. Ajayi and A. F. Attah and O. R. Awope and E. T. Ige and O. E. Omotoyinbo and B. J. Aladetuyi}
}
