<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>5</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">H. O. Faleke</style></author><author><style face="normal" font="default" size="100%">O. O. Alimi-Adeniran</style></author><author><style face="normal" font="default" size="100%">A. R. Oroye</style></author><author><style face="normal" font="default" size="100%">O. R. Awope</style></author><author><style face="normal" font="default" size="100%">O. O. Sowale</style></author><author><style face="normal" font="default" size="100%">O. R. Molehin</style></author><author><style face="normal" font="default" size="100%">A. F. Attah</style></author><author><style face="normal" font="default" size="100%">E. I. O. Ajayi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hormetic modulation of wound healing, catalase and cytochrome oxidase activities by cationic peptides of some African plant seeds</style></title><secondary-title><style face="normal" font="default" size="100%">Translating Research Findings into Policy in Developing Countries: Health, Infection and Treatment - Contributions from Humboldt Kolleg Osogbo-2017, Ed Olusola Ojurongbe</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2017</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.lap-publishing.com/catalog/details//store/gb/book/978-620-2-05009-8/translating-research-findings-into-policy-in-developing-countries?locale=gb</style></url></web-urls></urls><publisher><style face="normal" font="default" size="100%">Lambert Academic Publishing</style></publisher><pub-location><style face="normal" font="default" size="100%">Germany</style></pub-location><pages><style face="normal" font="default" size="100%">145-156</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Cytochrome oxidase is located at the end the electron transport system, where it catalyzes the re-oxidation of&lt;br&gt;the last cytochrome molecule in the chain. This final process results in the reduction of molecular oxygen to&lt;br&gt;water. The possible incomplete reduction of molecular oxygen leads to the production of reactive oxygen&lt;br&gt;species (ROS) or free radicals such as the superoxide anion and hydrogen peroxide which are very potent in&lt;br&gt;attacking membrane proteins, resulting in the formation of protein adduct, whose accumulation is toxic to the&lt;br&gt;cell. Endogenous cellular enzymes are available to quench the ROS and free radicals and thus eliminate the&lt;br&gt;toxic byproducts. These include superoxide dismutase and catalase which remove the superoxide free radical&lt;br&gt;and hydrogen peroxide, respectively. In this study, the hormetic properties of the cationic peptide fractions&lt;br&gt;were studied in relation to the modulation of wound healing and to the activities of cytochrome oxidase and&lt;br&gt;catalase in the hepatocytes of normal rats. The cationic peptide fractions were obtained from the seeds of&lt;br&gt;Carica papaya (PAW), Chrysophyllum albidum (AGB), Citrullus lanatus (WM), Citrus aurantium (ORG),&lt;br&gt;Thaumatococcus daniellii (TDS) using standard methods. Protein determination was done spectroscopically.&lt;br&gt;In vitro studies were carried out on liver mitochondrial and post-mitochondrial fraction, viz: cytochrome&lt;br&gt;oxidase and catalase activity assays, and using a tissue culture model for wound healing, the effects on tissue&lt;br&gt;regeneration of the cationic peptide-rich indigenous African seeds were also studied, in situ. Results showed&lt;br&gt;that the peptide extracts of Carica papaya and Citrullus lanatus seeds increased the cytochrome oxidase&lt;br&gt;activity present in the liver homogenate significantly at 605 nm while that of Thaumatococcus daniellii&lt;br&gt;significantly increased cytochrome oxidase in the mitochondrial fraction across 605 nm to 630 nm. Peptides&lt;br&gt;present in the seeds of Carica papaya, Citrullus lanatus, Thaumatococcus daniellii and Chrysophyllum&lt;br&gt;albidum were able to increase catalase activity in the mitochondrial fraction while they inhibited same in the&lt;br&gt;tissue homogenate. The peptides also enhanced rat hepatocyte wound healing to varying degrees.&lt;br&gt;Keywords: Hormesis, wound healing, catalase, cytochrome oxidase, cationic seed peptides&lt;/p&gt;</style></abstract></record></records></xml>