<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">E. I. O. Ajayi</style></author><author><style face="normal" font="default" size="100%">E. U. Modo</style></author><author><style face="normal" font="default" size="100%">A. O. Adebamowo</style></author><author><style face="normal" font="default" size="100%">U. C. Banerjee</style></author><author><style face="normal" font="default" size="100%">O. O. Tewe</style></author><author><style face="normal" font="default" size="100%">O. O. Olorunsogo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibitory Activity of Ethanol Extract of Manihot esculenta on MitochondrialMembrane Permeability Transition Pore and Caspase 3 in Type 2 Diabetes Mellitus</style></title><secondary-title><style face="normal" font="default" size="100%"> Int J. Biochem. Res. &amp; Rev. (IJBcRR)</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2016</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.journalrepository.org/media/journals/IJBCRR_3/2015/Dec/Ajayi942015IJBCRR23378.pdf</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">1-10</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;span&gt;The modulatory effect of different concentrations of ethanol extract of matured leaves of&amp;nbsp;&lt;/span&gt;&lt;em&gt;M. esculenta&lt;/em&gt;&lt;span&gt;, Crantz at 200, 600, 1000 and 1400 µg/ml was investigated&lt;/span&gt;&lt;em&gt;&amp;nbsp;in vitro&lt;/em&gt;&lt;span&gt;&amp;nbsp;on mitochondrial membrane permeability transition pore in liver, kidney and heart of diabetic animals in the absence and presence of 20 µM exogenous Ca&lt;/span&gt;&lt;span&gt;2+&lt;/span&gt;&lt;span&gt;. The extract at these concentrations had no significant (p&amp;lt; 0.05) effect on mitochondrial membrane permeability transition (MPT) pore of the three organs in the absence of Ca&lt;/span&gt;&lt;span&gt;2+&lt;/span&gt;&lt;span&gt;. However, in the presence of Ca&lt;/span&gt;&lt;span&gt;2+&lt;/span&gt;&lt;span&gt;, the extract exhibited significant (p&amp;lt; 0.05) inhibition of mitochondrial membrane transition pore opening: liver by 62.66%, 42.47%, 22.44% and 17.63% at 1400, 1000, 600, and 200 µg/ml, respectively. In the heart, inhibition of MMPT pore opening was by 92.86%, 71.43%, 64.29% and 57.14% at 200, 600, 1400, and 1000 µg/ml, respectively. In the kidney, the extract also inhibited mitochondrial membrane transition pore opening in a concentration-dependent manner by 92.65%, 91.18%, 89.71% and 72.06% at 1400, 1000, 600, and 200 µg/ml, respectively. Caspase-3 activity&amp;nbsp;&lt;/span&gt;&lt;em&gt;in vitro&lt;/em&gt;&lt;span&gt;&amp;nbsp;was also reduced with increasing extract concentrations; thus confirming that the extract inhibits MMPT pore opening in the presence of Ca&lt;/span&gt;&lt;span&gt;2+&lt;/span&gt;&lt;span&gt;. The extract may be able to protect these organs against damage, resulting from Ca&lt;/span&gt;&lt;span&gt;2+&lt;/span&gt;&lt;span&gt;&amp;nbsp;overload that may trigger cell death, and as such it may be useful in the management of diseases related to tissue wastage such as cardiomyopathy and nephropathy which are associated with Type 2 diabetes mellitus.&lt;/span&gt;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue></record></records></xml>