<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">E. I. O. Ajayi</style></author><author><style face="normal" font="default" size="100%">E. Ojediran</style></author><author><style face="normal" font="default" size="100%">G. Popoola</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Wound healing potential of Nauclea latifolia and Manihot esculenta leaf extract in Type 1 diabetic rats</style></title><secondary-title><style face="normal" font="default" size="100%">Afr. J. Trad. Compl. Alter. Med. (AJTCAM)</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2016</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://journals.sfu.ca/africanem/index.php/ajtcam/article/view/2809/2312</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1-5</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;span&gt;Background: This study was designed to ascertain this claim and to investigate the possible mechanism of action in relation to their phytochemical&amp;nbsp;&lt;/span&gt;&lt;span&gt;contents, using crude extracts of N. latifolia and M. esculenta leaves on topical wound in a rat model of Type 1 diabetes.&lt;/span&gt;&lt;br&gt;&lt;span&gt;Methods and Materials: The leaves were air-dried under shade and subjected to cold extraction in 95% ethanol. Normoglycaemic male Wistar rats&amp;nbsp;&lt;/span&gt;&lt;span&gt;were subjected to 2-month high-energy diet/ fat emulsion manipulation and injected with alloxan (150 mg/kg BW/day, i. p.). Fasting plasma glucose&amp;nbsp;&lt;/span&gt;&lt;span&gt;was determined after 7 days and rats with values exceeding 200 mg/dl were selected. 16 diabetic rats (120 – 180 g) were randomly assigned to four&amp;nbsp;&lt;/span&gt;&lt;span&gt;groups of four animals each. Wound was inflicted on the back of each rat by excision method. The crude extracts were topically applied over a period&amp;nbsp;&lt;/span&gt;&lt;span&gt;of 21 days. The scar tissues were removed at 7 days interval for collagen quantification and wound margin reduction was also monitored using&amp;nbsp;&lt;/span&gt;&lt;span&gt;tracing paper.&lt;/span&gt;&lt;br&gt;&lt;span&gt;Results: The crude extracts showed efficient wound healing activity as revealed by increased collagen content (scar tissues versus fresh wound&amp;nbsp;&lt;/span&gt;&lt;span&gt;tissues ab initio). Percentage wound closure also progressed significantly (p&amp;lt; 0.05) upon topical application of the extracts.&lt;/span&gt;&lt;br&gt;&lt;span&gt;Conclusion: The crude extract of N. latifolia leaves has proven to be more potent than that of M. esculenta in wound healing in Type I diabetic rats.&amp;nbsp;&lt;/span&gt;&lt;span&gt;It stimulated wound contraction and collagen formation, making it a promising natural product for further screening in search of new chemical&amp;nbsp;&lt;/span&gt;&lt;span&gt;entities that can be useful in diabetic wound management.&lt;/span&gt;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue></record></records></xml>