<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">M. A. Adeleke</style></author><author><style face="normal" font="default" size="100%">E. I. O. Ajayi</style></author><author><style face="normal" font="default" size="100%">Oyeniyi, T. T.</style></author><author><style face="normal" font="default" size="100%">Ajiboye, A. A.</style></author><author><style face="normal" font="default" size="100%">Ayoade, A. O.</style></author><author><style face="normal" font="default" size="100%">T. S. Ilori</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical and anti-plasmodial screening of threeselected tropical plants used for the treatment of malaria in Osogbo, Southwestern Nigeria</style></title><secondary-title><style face="normal" font="default" size="100%">J. Agric. Sc &amp; Tech. (JAGST)</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2013</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.ajol.info/index.php/jagst/article/view/112827</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">14-23</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The use of herbal remedy is featuring prominently as alternative to orthodox&amp;nbsp;medicine but little is known on scientific validation of their efficacies in malaria&amp;nbsp;treatment. Questionnaire survey was conducted in Osogbo metropolis to identify&amp;nbsp;the frequently used antiplasmodial herbal remedies. The aqueous extracts of the&amp;nbsp;three frequently used antimalaria herbs,&amp;nbsp;&lt;em style=&quot;font-size: initial;&quot;&gt;Mangifera indica&lt;/em&gt;&amp;nbsp;leaves,&amp;nbsp;&lt;em style=&quot;font-size: initial;&quot;&gt;Lawsonia inermis&amp;nbsp;&lt;/em&gt;leaves and&amp;nbsp;&lt;em style=&quot;font-size: initial;&quot;&gt;Enanthia chlorantha&lt;/em&gt;stem bark were prepared as described by herbal&amp;nbsp;vendors and subsequently analyzed for phytochemical constituents and antiplasmodial&amp;nbsp;efficiencies using mice model. The qualititave phytochemical analysis of&amp;nbsp;the extracts showed differences in the phytochemical constituents of the three&amp;nbsp;plants. The comparison of the parasite load before and after treatment showed that&amp;nbsp;the parasitamia level reduced significantly (p &amp;lt; 0.05) in the mice treated with&amp;nbsp;&lt;em style=&quot;font-size: initial;&quot;&gt;E.&amp;nbsp;chlorantha&lt;/em&gt;&amp;nbsp;and&amp;nbsp;&lt;em style=&quot;font-size: initial;&quot;&gt;M. indica&lt;/em&gt;&amp;nbsp;but increased significantly (p = 0.012; p &amp;lt; 0.05) in the group&amp;nbsp;treated with&amp;nbsp;&lt;em style=&quot;font-size: initial;&quot;&gt;L. inermis&lt;/em&gt;&amp;nbsp;while no parasite was detected in the group treated with&amp;nbsp;chloroquine (antimalaria drug) after treatment. The treated groups had higher&amp;nbsp;concentrations of creatinine, urea, bilirubin, Aspartate aminotransferase and&amp;nbsp;Alkaline phosphate in comparison with the control, an indication of the plant&amp;nbsp;extracts cyto‐toxicity. The results therefore showed that the extracts of&amp;nbsp;&lt;em style=&quot;font-size: initial;&quot;&gt;E.&amp;nbsp;chlorantha&lt;/em&gt;&amp;nbsp;and&amp;nbsp;&lt;em style=&quot;font-size: initial;&quot;&gt;M. indica&lt;/em&gt;&amp;nbsp;only possess chemosupressive not curative antimalaria&amp;nbsp;potential while&lt;em style=&quot;font-size: initial;&quot;&gt;&amp;nbsp;L. inermis&lt;/em&gt;&amp;nbsp;did not show any antiplasmodial effect. Further screening&amp;nbsp;on antimalaria herbal remedies therefore becomes imperative so as to guide the&amp;nbsp;policy on malaria treatment regime in Nigeria.&lt;/p&gt;
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&lt;p&gt;&lt;strong&gt;Key words&lt;/strong&gt;: Phytochemistry, antiplasmodial, plant extracts, biochemical markers&lt;/p&gt;
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&lt;/div&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue></record></records></xml>