@inbook {257,
	title = {Hormetic modulation of wound healing, catalase and cytochrome oxidase activities by cationic peptides of some African plant seeds},
	booktitle = {Translating Research Findings into Policy in Developing Countries: Health, Infection and Treatment - Contributions from Humboldt Kolleg Osogbo-2017, Ed Olusola Ojurongbe},
	year = {2017},
	pages = {145-156},
	publisher = {Lambert Academic Publishing},
	organization = {Lambert Academic Publishing},
	address = {Germany},
	abstract = {Cytochrome oxidase is located at the end the electron transport system, where it catalyzes the re-oxidation ofthe last cytochrome molecule in the chain. This final process results in the reduction of molecular oxygen towater. The possible incomplete reduction of molecular oxygen leads to the production of reactive oxygenspecies (ROS) or free radicals such as the superoxide anion and hydrogen peroxide which are very potent inattacking membrane proteins, resulting in the formation of protein adduct, whose accumulation is toxic to thecell. Endogenous cellular enzymes are available to quench the ROS and free radicals and thus eliminate thetoxic byproducts. These include superoxide dismutase and catalase which remove the superoxide free radicaland hydrogen peroxide, respectively. In this study, the hormetic properties of the cationic peptide fractionswere studied in relation to the modulation of wound healing and to the activities of cytochrome oxidase andcatalase in the hepatocytes of normal rats. The cationic peptide fractions were obtained from the seeds ofCarica papaya (PAW), Chrysophyllum albidum (AGB), Citrullus lanatus (WM), Citrus aurantium (ORG),Thaumatococcus daniellii (TDS) using standard methods. Protein determination was done spectroscopically.In vitro studies were carried out on liver mitochondrial and post-mitochondrial fraction, viz: cytochromeoxidase and catalase activity assays, and using a tissue culture model for wound healing, the effects on tissueregeneration of the cationic peptide-rich indigenous African seeds were also studied, in situ. Results showedthat the peptide extracts of Carica papaya and Citrullus lanatus seeds increased the cytochrome oxidaseactivity present in the liver homogenate significantly at 605 nm while that of Thaumatococcus danielliisignificantly increased cytochrome oxidase in the mitochondrial fraction across 605 nm to 630 nm. Peptidespresent in the seeds of Carica papaya, Citrullus lanatus, Thaumatococcus daniellii and Chrysophyllumalbidum were able to increase catalase activity in the mitochondrial fraction while they inhibited same in thetissue homogenate. The peptides also enhanced rat hepatocyte wound healing to varying degrees.Keywords: Hormesis, wound healing, catalase, cytochrome oxidase, cationic seed peptides},
	url = {https://www.lap-publishing.com/catalog/details//store/gb/book/978-620-2-05009-8/translating-research-findings-into-policy-in-developing-countries?locale=gb},
	author = {H. O. Faleke and O. O. Alimi-Adeniran and A. R. Oroye and O. R. Awope and O. O. Sowale and O. R. Molehin and A. F. Attah and E. I. O. Ajayi}
}
