@article {218,
	title = {Atherosclerosis plaque area reduction: working hypothesis to prevent cardiovascular event},
	journal = {Comparative Clinical Pathology},
	volume = {28},
	year = {2018},
	pages = {907-914},
	abstract = {Cardiovascular events are the leading cause of death worldwide. In this sense,\&nbsp;cardiovascular diseases (CVD) are the main products of atherosclerosis (ATR),\&nbsp;whose origin is multifactorial. The measurable identification of the so-called\&nbsp;cardiovascular risk factors (CRF) was a great advance for its prevention.\&nbsp;Scientific evidences have shown that the reduction of mortality due to\&nbsp;cardiovascular disease is an important achievement of the optimal control of\&nbsp;CRF. However, a large proportion of patients have cardiovascular events when\&nbsp;CRF is controlled. It is therefore imperative to stratify the patient{\textquoteright}s risk in\&nbsp;order to design the specific and individual treatment strategy. Currently, there\&nbsp;are cardiovascular risk classification (CVR) scales that contemplate the\&nbsp;combination of the multiple CRF that patients may present, although it is\&nbsp;known that most of these algorithms sub- or overestimate the possibility of\&nbsp;cardiovascular events. The incorporation of intermediate cardiovascular\&nbsp;surrogates to CRF and events, such as the measurement of carotid\&nbsp;atherosclerosis, is demonstrating an improvement in the diagnosis and fewer\&nbsp;events in the healthy population, with high cardiovascular risk, treated with\&nbsp;the incorporation of these to the diagnostic and therapeutic algorithms.
Keywords Prevention of cardiovascular event, Carotid atherosclerosis, Vascular Doppler, Hypertension, Prevention diet therapy},
	url = {https://doi.org/10.1007/s00580-018-2868-1},
	author = {Perez, H.A. and Allende, G.F. and E. I. O. Ajayi and Portal, D. J. and Garcia, N. H.}
}
