@article {206,
	title = {Wound healing potential of Nauclea latifolia and Manihot esculenta leaf extract in Type 1 diabetic rats},
	journal = {Afr. J. Trad. Compl. Alter. Med. (AJTCAM)},
	volume = {13},
	year = {2016},
	pages = {1-5},
	abstract = {Background: This study was designed to ascertain this claim and to investigate the possible mechanism of action in relation to their phytochemical\&nbsp;contents, using crude extracts of N. latifolia and M. esculenta leaves on topical wound in a rat model of Type 1 diabetes.Methods and Materials: The leaves were air-dried under shade and subjected to cold extraction in 95\% ethanol. Normoglycaemic male Wistar rats\&nbsp;were subjected to 2-month high-energy diet/ fat emulsion manipulation and injected with alloxan (150 mg/kg BW/day, i. p.). Fasting plasma glucose\&nbsp;was determined after 7 days and rats with values exceeding 200 mg/dl were selected. 16 diabetic rats (120 {\textendash} 180 g) were randomly assigned to four\&nbsp;groups of four animals each. Wound was inflicted on the back of each rat by excision method. The crude extracts were topically applied over a period\&nbsp;of 21 days. The scar tissues were removed at 7 days interval for collagen quantification and wound margin reduction was also monitored using\&nbsp;tracing paper.Results: The crude extracts showed efficient wound healing activity as revealed by increased collagen content (scar tissues versus fresh wound\&nbsp;tissues ab initio). Percentage wound closure also progressed significantly (p\&lt; 0.05) upon topical application of the extracts.Conclusion: The crude extract of N. latifolia leaves has proven to be more potent than that of M. esculenta in wound healing in Type I diabetic rats.\&nbsp;It stimulated wound contraction and collagen formation, making it a promising natural product for further screening in search of new chemical\&nbsp;entities that can be useful in diabetic wound management.},
	url = {http://journals.sfu.ca/africanem/index.php/ajtcam/article/view/2809/2312},
	author = {E. I. O. Ajayi and E. Ojediran and G. Popoola}
}
