@article {204,
	title = {Phytochemical and anti-plasmodial screening of threeselected tropical plants used for the treatment of malaria in Osogbo, Southwestern Nigeria},
	journal = {J. Agric. Sc \& Tech. (JAGST)},
	volume = {16},
	year = {2013},
	pages = {14-23},
	abstract = {The use of herbal remedy is featuring prominently as alternative to orthodox\&nbsp;medicine but little is known on scientific validation of their efficacies in malaria\&nbsp;treatment. Questionnaire survey was conducted in Osogbo metropolis to identify\&nbsp;the frequently used antiplasmodial herbal remedies. The aqueous extracts of the\&nbsp;three frequently used antimalaria herbs,\&nbsp;Mangifera indica\&nbsp;leaves,\&nbsp;Lawsonia inermis\&nbsp;leaves and\&nbsp;Enanthia chloranthastem bark were prepared as described by herbal\&nbsp;vendors and subsequently analyzed for phytochemical constituents and antiplasmodial\&nbsp;efficiencies using mice model. The qualititave phytochemical analysis of\&nbsp;the extracts showed differences in the phytochemical constituents of the three\&nbsp;plants. The comparison of the parasite load before and after treatment showed that\&nbsp;the parasitamia level reduced significantly (p \&lt; 0.05) in the mice treated with\&nbsp;E.\&nbsp;chlorantha\&nbsp;and\&nbsp;M. indica\&nbsp;but increased significantly (p = 0.012; p \&lt; 0.05) in the group\&nbsp;treated with\&nbsp;L. inermis\&nbsp;while no parasite was detected in the group treated with\&nbsp;chloroquine (antimalaria drug) after treatment. The treated groups had higher\&nbsp;concentrations of creatinine, urea, bilirubin, Aspartate aminotransferase and\&nbsp;Alkaline phosphate in comparison with the control, an indication of the plant\&nbsp;extracts cyto-toxicity. The results therefore showed that the extracts of\&nbsp;E.\&nbsp;chlorantha\&nbsp;and\&nbsp;M. indica\&nbsp;only possess chemosupressive not curative antimalaria\&nbsp;potential while\&nbsp;L. inermis\&nbsp;did not show any antiplasmodial effect. Further screening\&nbsp;on antimalaria herbal remedies therefore becomes imperative so as to guide the\&nbsp;policy on malaria treatment regime in Nigeria.



Key words: Phytochemistry, antiplasmodial, plant extracts, biochemical markers

},
	url = {https://www.ajol.info/index.php/jagst/article/view/112827},
	author = {M. A. Adeleke and E. I. O. Ajayi and Oyeniyi, T. T. and Ajiboye, A. A. and Ayoade, A. O. and T. S. Ilori}
}
